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Thrombotic Microangiopathy Causing Acute Kidney Injury in a COVID-19 Patient

Amitabh Kulkarni1, Prashant Nasa2, Srinivasa Polumuru3

  • 1Department of Nephrology, NMC Specialty Hospital, PO Box 7832, Al Nahda 2, Dubai, UAE.

Indian Journal of Nephrology
|January 24, 2022
PubMed

Insights

Acute Kidney Injury (AKI) is common in COVID-19 patients, leading to higher mortality. This case reveals a young woman

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Immunology

Background:

  • Acute Kidney Injury (AKI) is a frequent complication in COVID-19 patients, associated with increased mortality.
  • The mechanisms of AKI in COVID-19 are diverse, including direct viral effects, immune responses, and hypercoagulability.

Observation:

  • A young female patient with severe COVID-19 presented with AKI.
  • The patient had a history of chronic kidney disease, potentially linked to IgA nephropathy.

Findings:

  • The patient's AKI was attributed to complement-3 mediated thrombotic microangiopathy.
  • This suggests a specific immune-driven pathway contributing to kidney damage in COVID-19.

Implications:

  • Highlights the complex pathophysiology of AKI in COVID-19, involving immune system dysregulation.
  • Underscores the importance of considering thrombotic microangiopathy in COVID-19 patients with AKI and pre-existing kidney conditions.
  • Suggests potential targets for therapeutic interventions in managing AKI during COVID-19.

Keywords:
AKICOVID-19TMAcomplement mediated microangiopathy

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