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Updated: Oct 5, 2025
Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry
Published on: January 28, 2017
Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model
Yan-Dong Miao1, Jiang-Tao Wang2, Xiao-Long Tang2
1The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China. miaoyd19@lzu.edu.cn.
Abstract:
CXCL12 expression was significantly lower in tumor samples than in corresponding normal samples. CXCL12 expression was significantly positively related to the infiltration levels of T cells, dendritic cells (DCs), immature DCs, cytotoxic cells, Tfh cells, mast cells, B cells, Th1 cells, natural killer (NK) cells, pDCs, neutrophils, and T helper cells (Spearman correlation coefficient > 0.5, P < 0.001) and negatively correlated with the infiltration level of NK CD56bright cells. In addition, pancreatic hTERT-HPNE cells treated with three diverse CXCL12 isoforms exhibited changes mainly in the regulation of the epithelial-mesenchymal transition activation pathway.
