Related Experiment Video
Updated: Oct 5, 2025
14:08
Study of Protein-protein Interactions in Autophagy Research
Published on: September 9, 2017
9.3K
Reciprocal interactions between gut microbiota and autophagy.
Pierre Lapaquette1, Jean-Baptiste Bizeau2, Niyazi Acar2
1UMR PAM A 02.102, University Bourgogne Franche-Comté, Agrosup Dijon, Dijon 21000, France.
World Journal of Gastroenterology
|January 24, 2022
Summary
The gut microbiota and host autophagy maintain a symbiotic balance crucial for health. Disruptions in this relationship can lead to disease, highlighting autophagy
Area of Science:
- Microbiology
- Cell Biology
- Host-Microbe Interactions
Background:
- The gut microbiota and host form a symbiotic relationship, influencing health and disease.
- Autophagy, a cellular process, maintains homeostasis and responds to stress.
- Dysbiosis and host stress disrupt the gut symbiotic equilibrium.
Purpose of the Study:
- To review the bidirectional relationship between gut microbiota and host autophagy.
- To explore how gut microbes modulate autophagy in the gut and periphery.
- To examine autophagy's role in regulating the gut microbiota.
Main Methods:
- Literature review of studies on gut microbiota and autophagy.
- Analysis of molecular and cellular mechanisms involved.
- Synthesis of current research on host-microbe-autophagy interactions.
Main Results:
- Gut microbiota significantly modulates host autophagy locally and systemically.
- Autophagy influences the composition and function of the gut microbiota.
- This interplay is critical for maintaining gut homeostasis and host health.
Conclusions:
- Autophagy is a key mediator in the gut microbiota-host dialogue.
- Targeting autophagy presents potential therapeutic strategies for gut dysbiosis.
- Further research is needed to fully elucidate these complex interactions.
Related Concept Videos
01:27Autophagy
4.7K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.7K
01:36Delivery Pathways to the Lysosome
8.1K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
8.1K
01:18Autophagic Cell Death
3.6K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
3.6K
01:01Autocrine Signaling
49.1K
Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
49.1K
00:58Recycling Endosomes and Transcytosis
2.9K
The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
2.9K
01:29Bacterial Flora of the Large Intestine
719
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
719