Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a spatial radiomics nomogram for predicting unfavorable outcomes after acute ischemic stroke: A multicenter study.

European journal of radiology·2026
Same author

Refined AI-ASPECTS with modified atlas and lesion-load thresholds: advancing acute ischemic stroke imaging and prognostic prediction.

BMC medicine·2026
Same author

The Relationship between Glymphatic Dysfunction and Post-stroke Cognitive Impairment.

Current medical imaging·2026
Same author

Aneurysm Wall Enhancement in Patients With Unruptured Intracranial Aneurysm Using Aspirin or Statins: A Cross-Sectional Analysis of Three Prospective Cohorts.

AJNR. American journal of neuroradiology·2026
Same author

A Location-Specific Hyperdense Area Score Predicts Severe Mass Effect after Thrombectomy.

Neurocritical care·2026
Same author

Stage-Related Alterations in Cortical Functional Connectivity Gradients in Non-Dialysis Patients With Chronic Kidney Disease.

AJNR. American journal of neuroradiology·2026

Related Experiment Video

Updated: Oct 5, 2025

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
09:54

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

12.2K

Abnormal Static and Dynamic Functional Network Connectivity in Patients With Presbycusis.

Chunhua Xing1, Yu-Chen Chen1, Song'an Shang1

  • 1Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Frontiers in Aging Neuroscience
|January 24, 2022
PubMed
Summary

This study found altered functional network connectivity (FNC) in individuals with presbycusis, linking these changes to cognitive impairments. These findings suggest FNC may be a biomarker for cognitive decline in presbycusis.

Keywords:
cognitive impairmentdynamic functional network connectivityfunctional magnetic resonance imagingpresbycusisstatic functional network connectivity

More Related Videos

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.4K
Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R
06:01

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Published on: December 9, 2022

2.6K

Related Experiment Videos

Last Updated: Oct 5, 2025

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
09:54

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

12.2K
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.4K
Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R
06:01

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Published on: December 9, 2022

2.6K

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Cognitive Science

Background:

  • Presbycusis, or age-related hearing loss, is associated with cognitive decline.
  • Understanding the neural underpinnings of cognitive changes in presbycusis is crucial for developing targeted interventions.

Purpose of the Study:

  • To investigate abnormal static and dynamic functional network connectivity (FNC) in patients with presbycusis.
  • To explore the association between altered FNC and cognitive function in this population.

Main Methods:

  • Resting-state functional MRI (rs-fMRI) was used to assess FNC in 60 patients with presbycusis and 60 healthy controls.
  • Independent component analysis (ICA) identified eight resting-state networks (RSNs).
  • Static and dynamic FNCs (sFNC and dFNC) were analyzed and correlated with cognitive scores.

Main Results:

  • Patients with presbycusis showed decreased sFNC in the default mode network (DMN)-left frontoparietal network (LFPN) and attention network (AN)-cerebellum network (CN) pairs.
  • Abnormal dynamic FNCs (dFNCs) and altered temporal characteristics (shorter mean dwell time and fraction time in State 3) were observed in the presbycusis group.
  • Decreased sFNC in the DMN-LFPN pair correlated negatively with TMT-B scores, indicating poorer executive function.

Conclusions:

  • Presbycusis is characterized by distinct alterations in both static and dynamic functional network connectivity.
  • Aberrant FNC patterns in presbycusis are associated with impaired cognitive performance.
  • Functional network connectivity shows potential as a biomarker for tracking cognitive impairment in presbycusis.