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Published on: March 1, 2024
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Cardiovascular comorbidities in psoriasis (Review).
Daciana Elena Branisteanu1, Alin Codrut Nicolescu2, Daniel Constantin Branisteanu3
1Department of Dermatology, Faculty of Medicine 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.
Experimental and Therapeutic Medicine
|January 24, 2022
Summary
Psoriasis is an immune-mediated disease linked to serious cardiovascular issues like heart disease and stroke. Understanding these connections is crucial for better patient management and treatment strategies.
Area of Science:
- Immunology
- Dermatology
- Cardiology
Background:
- Psoriasis, once viewed as a skin condition, is now recognized as a systemic immune-mediated inflammatory disease.
- It presents with skin lesions and significant systemic comorbidities, including psoriatic arthritis, cardiovascular disease, metabolic syndrome, and inflammatory bowel disease.
- Psoriasis is an independent risk factor for cardiovascular disease, contributing to conditions like ischemic heart disease, hypertension, and stroke.
Purpose of the Study:
- To review current knowledge on cardiovascular comorbidities associated with psoriasis.
- To emphasize the link between chronic inflammation in psoriasis and the development of atherosclerosis.
- To inform optimal patient management strategies by understanding these associations.
Main Methods:
- Literature review of current scientific knowledge.
- Analysis of the etiopathogenic mechanisms linking psoriasis to cardiovascular disease.
- Evaluation of the potential impact of biological therapies on atherosclerosis.
Main Results:
- Psoriasis significantly increases the risk of cardiovascular events, including heart attack and stroke.
- Chronic inflammation and specific cytokines in psoriasis are implicated in the development of atherosclerosis.
- Biological therapies show potential in managing atherosclerosis progression in psoriasis patients.
Conclusions:
- Psoriasis is a systemic disease with profound cardiovascular implications.
- Effective management of psoriasis may help mitigate cardiovascular risk.
- Further research into the interplay between psoriasis and cardiovascular health is warranted.
