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Published on: March 24, 2023
Liver function in COVID-19 infection.
Dagmara Przekop1, Ewa Gruszewska2, Lech Chrostek3
1Diagnostics-Experimental Center of Sexually Transmissible Diseases, Bialystok 15-879, Poland.
COVID-19 (Coronavirus disease 2019) can cause liver injury, affecting liver function tests. Monitoring these tests is crucial for assessing disease severity and treatment impact in SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) patients.
Area of Science:
- Hepatology
- Virology
- Internal Medicine
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a multi-organ affecting illness.
- Liver function abnormalities are frequently observed in patients with COVID-19.
- Understanding the mechanisms and clinical implications of COVID-19-related liver injury is essential.
Purpose of the Study:
- To review current knowledge on liver injury in SARS-CoV-2 infection.
- To discuss potential mechanisms of liver damage.
- To highlight the role of liver function tests in evaluating disease severity and treatment response.
Main Methods:
- Literature review of studies on COVID-19 and liver injury.
- Analysis of reported liver function test abnormalities.
- Examination of factors influencing liver injury and test results.
Main Results:
- COVID-19-associated liver injury is linked to patient demographics (age, sex), disease severity, comorbidities, and pre-existing conditions.
- Antiviral treatments for SARS-CoV-2 can influence liver function, potentially increasing liver enzyme levels.
- Variations in liver function tests are critical indicators for assessing the progression of liver injury.
Conclusions:
- Liver injury is a significant complication of COVID-19.
- Liver function tests are vital for monitoring disease progression and guiding clinical management.
- Further research into the specific mechanisms of SARS-CoV-2-induced liver damage is warranted.
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