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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

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Patients with Dipper and Nondipper High-Normal Blood Pressure Were Associated with Left Ventricular Mass

Fan-Kai Xiao1,2, Ping Li3, Zhan-Ying Han2

  • 1Oncology Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

International Journal of Hypertension
|January 24, 2022
PubMed

Insights

High-normal blood pressure is linked to increased left ventricular mass index (LVMI), especially in nondippers. Circadian blood pressure variations may contribute to left ventricular hypertrophy.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Clinical Investigation

Background:

  • High-normal blood pressure is a potential risk factor for cardiovascular complications.
  • Left ventricular mass index (LVMI) is a marker of cardiac remodeling and a predictor of cardiovascular events.

Purpose of the Study:

  • To investigate the association between high-normal blood pressure and left ventricular mass index (LVMI).
  • To explore differences in LVMI between dipper and nondipper individuals within the high-normal blood pressure category.

Main Methods:

  • 181 participants were assessed for office blood pressure and underwent 24-hour ambulatory blood pressure monitoring (ABPM).
  • Participants were categorized into normotensive (<130/85 mmHg) and high-normal blood pressure (130-139/85-89 mmHg) groups.
  • The high-normal blood pressure group was further classified into dipper and nondipper based on ABPM patterns; LVMI was calculated using echocardiography.

Main Results:

  • Nondipper individuals with high-normal blood pressure exhibited significantly higher mean 24-hour systolic blood pressure and LVMI compared to dippers.
  • Higher nocturnal blood pressure was significantly associated with the nondipper group.
  • Multivariate regression identified triglyceride, total cholesterol, LDL-C, and blood pressure variability as independent predictors of LVMI.

Conclusions:

  • Abnormalities in circadian blood pressure variability, particularly in nondippers with high-normal blood pressure, are associated with increased LVMI.
  • These findings suggest that circadian blood pressure patterns may play a role in the development of left ventricular hypertrophy even in the high-normal range.
Abstract

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