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Updated: Oct 5, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Analysis of Disease Patterns in Patients with Unilateral Sinonasal Diseases: A Tertiary Care Hospital Experience
Savita Lasrado1, Shaista Naaz1, Kuldeep Moras1
1Department of Otorhinolaryngology and Head and Neck Surgery, Father Muller Medical College, Mangalore, India.
Aims:
The aim of the present study was to evaluate the clinicopathological profile of sinonasal masses and to identify features suggestive of neoplastic pathology.
Materials And Methods:
A retrospective review of all sinonasal masses in patients attending a tertiary care hospital between April 2019 to Feb 2020 presenting at a tertiary care hospital were analysed. The demographic data, presenting symptoms, radiological and histopathological diagnosis were analysed.
Results:
In the present study total 23 patients with age ranging from 8 to 72 years were analysed. The overall M:F ratio was 1.55:1. Most of the patients (56%) belong to 31-60 year age group. The main presenting symptoms were nasal obstruction and rhinorrhoea. Epistaxis and extranasal symptoms like facial pain, dental and orbital complaints were found to be higher in neoplastic conditions. The number of non-neoplastic lesions were more than neoplastic with 78.2% being reported to be antrochoanal polyp and ethmoidal polyps, 8.69% being inverted papillomas and 13% cases were histopathologically reported to be malignant. Neoplastic conditions were significantly commoner in males and in the age group 40-60 years.
Conclusion:
We concluded that clinical, radiologic, and histopathological evaluation is essential for proper diagnosis and stress the importance of immunohistochemistry which is the ultimate diagnostic technique in certain neoplastic lesions.
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