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Delayed Presentation in Chiari Malformation.

Muhammad Rafay¹, Farhan Gulzar¹, Hassan Masood Jafri¹

¹Department of Neurosurgery, Liaquat National Hospital, Karachi, Pakistan.

Asian Journal of Neurosurgery

|January 24, 2022

Summary

Clinical presentations of Chiari malformations in our population differ from previous studies, with motor weakness being the most common symptom. Delayed diagnosis and lack of awareness contribute to these differences.

Keywords:

Chiari presentation chiari clinical symptoms

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Area of Science:

Neurology
Neurosurgery
Clinical Medicine

Background:

Chiari malformations encompass diverse clinicopathological entities with varied presentations, pathophysiology, and outcomes.
Understanding typical clinical presentations is crucial for timely diagnosis and management.
Delayed initial presentation can alter the characteristic signs and symptoms observed in patients.

Purpose of the Study:

To observe and document the distinct clinical presentations of Chiari malformation patients within a specific population.
To investigate potential differences in presentation compared to existing literature.
To explore the impact of delayed diagnosis on clinical manifestation.

Main Methods:

A cross-sectional observational study involving prospectively collected data from 46 Chiari malformation patients.
Data collected between 2017 and 2020 and analyzed using SPSS Version 25.
Qualitative data presented as frequencies/percentages; quantitative data as mean ± standard deviation. Chi-square test used for categorical variable association (P ≤ 0.05 significance).

Main Results:

Motor weakness was the most frequent presenting symptom in 36% of patients.
Sensory deficit was the second most common presentation.
This contrasts with prior literature where headache was reported as the most common initial symptom.

Conclusions:

The clinical presentation of Chiari malformations in this population diverges from established reports.
Delayed patient presentation and limited disease awareness are identified as key contributing factors to these observed differences.
These factors likely influence disease outcomes and treatment effectiveness.