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Long Noncoding RNA LIFR-AS1: A New Player in Human Cancers

Zhiqun Bai1, Xuemei Wang1, Zhen Zhang1

  • 1The First Affiliated Hospital of China Medical University, Department of Ultrasonic Diagnosis, No. 155 Nanjing North Street, Heping District, Shenyang, Liaoning 110001, China.

Biomed Research International
|January 24, 2022
PubMed

Insights

Long noncoding RNAs (lncRNAs) like LIFR-AS1 are crucial in cancer development. This review explores LIFR-AS1

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in tumorigenesis.
  • Leukemia inhibitory factor receptor antisense RNA1 (LIFR-AS1) is a novel lncRNA transcribed from the LIFR gene.
  • Aberrant LIFR-AS1 expression is linked to various cancer hallmarks.

Purpose of the Study:

  • To review the multifaceted roles of LIFR-AS1 in cancer development and progression.
  • To highlight LIFR-AS1's potential as a diagnostic biomarker and therapeutic target in human cancers.

Main Methods:

  • Comprehensive literature review of studies investigating LIFR-AS1 in various cancer types.
  • Analysis of reported mechanisms by which LIFR-AS1 influences tumor biology.
  • Evaluation of clinical data correlating LIFR-AS1 expression with clinicopathological features.

Main Results:

  • LIFR-AS1 participates in regulating tumor proliferation, migration, invasion, and apoptosis.
  • Its expression levels correlate with tumor characteristics and patient outcomes.
  • LIFR-AS1 influences cancer drug resistance through distinct molecular pathways.

Conclusions:

  • LIFR-AS1 is a significant player in the pathogenesis of diverse cancers.
  • LIFR-AS1 holds promise as a valuable biomarker for cancer diagnosis and prognosis.
  • Targeting LIFR-AS1 presents a potential therapeutic strategy for cancer treatment.

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