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Consensus statement on safety measures for pressurized intraperitoneal aerosol chemotherapy
Arnaud Girardot-Miglierina1, Daniel Clerc1, Mohammad Alyami2
1Department of Visceral Surgery, Lausanne University Hospital CHUV, University of Lausanne (UNIL), Lausanne, Switzerland.
Caregivers in the operating room face risks during Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC). A consensus was reached on a comprehensive safety protocol to mitigate these risks for healthcare professionals.
Area of Science:
- Oncology
- Surgical Oncology
- Patient Safety
Background:
- Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) offers a promising approach for treating peritoneal cancer.
- However, PIPAC presents potential occupational hazards for operating room (OR) personnel.
Purpose of the Study:
- To establish a consensus-driven, comprehensive safety protocol for PIPAC procedures.
- To address and minimize risks for healthcare providers involved in PIPAC administration.
Main Methods:
- A two-round Delphi process involving 47 participants from active PIPAC centers.
- Utilized the GRADE framework for evaluating the strength of recommendations based on existing evidence.
Main Results:
- Consensus achieved on 41 out of 43 (95.3%) predefined safety items.
- Strong and weak recommendations were established for 30 and 10 items, respectively.
- Laminar airflow was recommended; consensus was not reached on specific glove changes or mask use for varying exposure risks.
Conclusions:
- A high level of agreement was achieved for a detailed PIPAC safety protocol tailored to caregiver exposure risks.
- This consensus provides a foundation for educating staff and improving adherence to safety practices in PIPAC procedures.
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