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Endoplasmic reticulum-translocation is essential for APOL1 cellular toxicity

Etty Kruzel-Davila1,2, Ira Bavli-Kertselli1, Ayala Ofir1

  • 1Department of Nephrology, Rambam Health Care Campus, Haifa, Israel.

Iscience
|January 24, 2022
PubMed
Summary

Blocking APOL1 toxicity may prevent chronic kidney disease (CKD). Deleting specific amino acids or targeting ER translocation shows promise in mitigating APOL1-associated kidney damage in at-risk populations.

Keywords:
Cell biologyCellular physiologyFunctional aspects of cell biology

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