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Colloids

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...

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Related Experiment Video

Updated: Oct 5, 2025

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Published on: July 28, 2022

Assembling anisotropic colloids using curvature-mediated lipid sorting.

Manoj Kumar¹, Anupam Singh¹, Benedetta Del Secco²

¹Simons Centre for the Study of Living Machines, National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India. manojk@ncbs.res.in.

|January 24, 2022

Summary

Researchers used colloid supported lipid bilayers (CSLBs) to create shape-anisotropic patchy colloids. These colloids enable the directed assembly of colloidal links, paving the way for novel colloidal structures.

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Last Updated: Oct 5, 2025

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

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Published on: July 28, 2022

Formation of Biomembrane Microarrays with a Squeegee-based Assembly Method

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Published on: May 8, 2014

A Nanobar-Supported Lipid Bilayer System for the Study of Membrane Curvature Sensing Proteins in vitro

A Nanobar-Supported Lipid Bilayer System for the Study of Membrane Curvature Sensing Proteins in vitro

Published on: November 30, 2022

Area of Science:

Soft Matter Physics
Materials Science
Colloid Science

Background:

Colloid supported lipid bilayers (CSLBs) are emerging as a platform for assembling colloidal structures.
Understanding lipid behavior on anisotropic colloids is crucial for designing advanced materials.

Purpose of the Study:

To investigate lipid sorting on anisotropic colloids driven by membrane curvature.
To engineer shape-anisotropic patchy colloids for directed self-assembly.
To demonstrate the formation of colloidal links using these engineered colloids.

Main Methods:

Formation of multi-component lipid bilayer membranes around anisotropic colloids.
Exploiting curvature-sensitive lipid sorting to create membrane patches.
Utilizing biotinylated lipids and streptavidin for patch functionalization.
Demonstrating directed assembly of colloidal links.

Main Results:

Curvature anisotropy of colloids drives lipid sorting along the colloidal surface.
Self-assembly of functionalized membrane patches at specific locations on 'hexapod' colloids.
Successful directed assembly of colloidal links, forming flexible structures.

Conclusions:

Shape-anisotropic patchy colloids can be reliably fabricated using curvature-driven lipid sorting.
This method allows for precise control over colloidal assembly.
The developed approach enables the creation of complex, heterogeneous, and flexible colloidal architectures.