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Factor XIII and surgical bleeding.

Patricia Guilabert1, Lars Asmis2, Vicente Cortina3

  • 1Department of Anesthesia and Critical Care, Vall d'Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain - patricia.guilabert@gmail.com.

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Summary
This summary is machine-generated.

Factor XIII (FXIII) deficiency, though rare in congenital forms, is more common in acquired cases. This review guides clinicians on suspecting, diagnosing, and treating FXIII deficiency, particularly in surgical settings.

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Area of Science:

  • Hematology
  • Coagulation Science

Background:

  • Factor XIII (FXIII) is crucial for stabilizing fibrin clots and wound healing.
  • FXIII deficiency is often overlooked due to perceived rarity, impacting clinical consideration.
  • While congenital FXIII deficiency is rare (1 in a million), acquired forms are more prevalent.

Purpose of the Study:

  • To provide guidance on suspecting and diagnosing FXIII deficiency.
  • To clarify when and why FXIII deficiency should be considered in clinical practice.
  • To analyze current evidence on the treatment of FXIII deficiency.

Main Methods:

  • Literature review of scientific evidence regarding FXIII deficiency.
  • Analysis of diagnostic approaches in preoperative and surgical contexts.
  • Examination of treatment strategies for FXIII deficiency.

Main Results:

  • FXIII deficiency can arise from impaired synthesis, overconsumption, or autoantibody degradation.
  • Clinical suspicion and diagnosis are essential, especially in surgical patients.
  • Effective treatment strategies exist for FXIII deficiency.

Conclusions:

  • Clinicians should be aware of FXIII deficiency, particularly acquired forms.
  • Timely diagnosis and appropriate management are critical for patient outcomes.
  • Further research may enhance understanding and treatment of FXIII deficiency.