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Experimental animal models for denture stomatitis: A methodological review.

Gustavo S Moraes1, Thaís Albach1, Carolina Yc Sugio2

  • 1Department of Dentistry, 67883State University of Ponta Grossa, State University of Ponta Grossa, Brazil.

Laboratory Animals
|January 24, 2022
PubMed
Summary

Denture stomatitis, an oral inflammation linked to Candida albicans, affects denture wearers. This review examines existing animal models for denture stomatitis to guide the development of effective treatments.

Keywords:
Animal modelsCandida albicansdenture stomatitisoral candidiasis

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Area of Science:

  • Oral pathology and mycology
  • Infectious diseases
  • Biomedical research models

Background:

  • Denture stomatitis is the most common oral candidiasis and lesion in denture wearers.
  • Characterized by inflammation (edema, erythema, hyperplasia) of the denture-bearing mucosa, primarily the palate.
  • Mainly caused by *Candida albicans* infection, it presents high treatment failure rates.

Purpose of the Study:

  • To review existing *in vivo* models for denture stomatitis.
  • To provide an overview of methodological differences in these models.
  • To inform the development of a suitable animal model for testing alternative therapies.

Main Methods:

  • Systematic review of literature on denture stomatitis animal models over the past 40 years.
  • Analysis of various approaches used, including antibiotic and immunosuppressor protocols.
  • Comparison of methodological variations across different developed models.

Main Results:

  • Multiple animal models have been developed to study denture stomatitis pathogenesis and evaluate treatments.
  • Significant methodological differences exist among these models.
  • Further investigation is needed to determine optimal protocols for model development.

Conclusions:

  • Establishing a robust *in vivo* model is crucial for advancing denture stomatitis research.
  • Understanding methodological variations is key to selecting or developing an appropriate model.
  • Continued research into specific protocols (e.g., antibiotics, immunosuppressors) is necessary for effective model creation.