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Updated: Oct 5, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Extending the Reach of Antimicrobial Stewardship to Pediatric Patients
Tracy N Zembles1,2, Natasha Nakra3, Sarah K Parker4
1Department of Enterprise Safety, Children's Wisconsin, Milwaukee, WI, USA. tzembles@chw.org.
Abstract:
Guidance for developing and implementing antimicrobial stewardship programs for children is lacking. This review article describes unique considerations for planning antimicrobial management of children that may impact stewardship strategies. A variety of methods and training tools are described along with metrics specific to measuring antibiotic use and outcomes in children. Handshake stewardship is specifically explained and is considered a best practice. Information on stewardship in unique settings, including the neonatal intensive care unit and outpatient settings, are included.
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