Precise Control of Radial Catenane Synthesis via Clipping and Pumping
Anquan Li1, Zhengqi Tan1, Yiheng Hu1
1School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.
Abstract:
An unprecedented molecular pumping cassette was designed and implemented for the construction of molecular necklaces, that is, radial [n]catenanes. The mechanism was fully confirmed on a model [2]pseudorotaxane, and the novel clipping-followed-by-pumping strategy was used to prepare a series of [n]catenanes (n = 2-5). A pair of [3]catenane diastereomers sequentially threaded with two different wheels was also accomplished. The success of utilizing molecular pumping to construct molecular necklaces offers new insights into complex molecular architectures and expands the application of molecular machines in synthesis.
More Related Videos
Related Concept Videos
Ziegler–Natta Chain-Growth Polymerization: Overview
Radical Chain-Growth Polymerization: Overview
Cationic Chain-Growth Polymerization: Mechanism
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Woodward–Hoffmann Selection Rules and Microscopic Reversibility
Electrophilic Addition of HX to 1,3-Butadiene: Thermodynamic vs Kinetic Control


