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Updated: Oct 5, 2025

Author Spotlight: An Accurate and Quantitative Approach to Study Visual Feature Selectivity of the Optokinetic Reflex in Mice
Published on: June 23, 2023
Models of the optokinetic system
1Late Professor of Ophthalmology, Biomedical Engineering and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Abstract:
This chapter starts by comparing two different models to account for optokinetic-vestibular symbiosis. In the first, there are two separate velocity storage (integrator) elements for vestibular and optokinetic systems, and in the second model, velocity storage is shared between the two systems. Behavioral and electrophysiological evidence is presented to support the model with shared velocity storage and its ability to provide a linear addition of vestibular and optokinetic signals, account for different time constants of optokinetic and vestibular responses and separate adaptive properties of the two systems. This model is then extended to account for an unexplained clinical disorder-periodic alternating nystagmus-and provide insights into its pathogenesis and treatment.
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