Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.2K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gamma Knife, its optimal use - a Letter.

British journal of neurosurgery·2026
Same author

The Reformation.

Progress in brain research·2024
Same author

Two surgical instruments.

Progress in brain research·2024
Same author

Cranial sutures.

Progress in brain research·2024
Same author

The meninges.

Progress in brain research·2024
Same author

The pericranium.

Progress in brain research·2024

Related Experiment Video

Updated: Oct 5, 2025

Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy
03:13

Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy

Published on: June 28, 2024

872

Less common extracerebral tumors.

Jeremy C Ganz1

  • 1Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway.

Progress in Brain Research
|January 25, 2022
PubMed
Summary

Gamma Knife radiosurgery (GKNS) shows effectiveness for benign extraparenchymal skull base tumors. For malignant tumors, GKNS plays a supportive role, with more limited evidence.

Keywords:
AngiofibromaCavernous hemangiomaChondrosarcomaChordomaEsthesioneuroblastomaHemangiopericytomaNasopharyngeal carcinomaParagangliomaSchwannomaSolitary fibrous tumor

More Related Videos

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
07:14

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice

Published on: May 23, 2025

713
Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
05:39

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

593

Related Experiment Videos

Last Updated: Oct 5, 2025

Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy
03:13

Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy

Published on: June 28, 2024

872
Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
07:14

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice

Published on: May 23, 2025

713
Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
05:39

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

593

Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Extraparenchymal skull base tumors present diverse therapeutic challenges.
  • Gamma Knife radiosurgery (GKNS) is a precise radiation technique.
  • Evaluating GKNS efficacy for various tumor types is crucial.

Purpose of the Study:

  • To assess the outcomes of Gamma Knife radiosurgery (GKNS) for both benign and malignant extraparenchymal skull base tumors.
  • To delineate the role of GKNS in managing these complex lesions.

Main Methods:

  • Review of clinical data and treatment outcomes for patients with extraparenchymal skull base tumors treated with GKNS.
  • Analysis of efficacy based on tumor histology (benign vs. malignant).

Main Results:

  • GKNS demonstrates significant effectiveness across a wide range of benign extraparenchymal skull base tumors.
  • For malignant extraparenchymal tumors, the evidence for GKNS is more limited, indicating a primarily supportive role.

Conclusions:

  • GKNS is a highly effective treatment modality for benign extraparenchymal skull base tumors.
  • The application of GKNS in malignant extraparenchymal skull base tumors warrants further investigation, with current data suggesting a supplementary treatment strategy.