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Updated: Oct 5, 2025
Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy
Published on: June 28, 2024
Less common intraparenchymal tumors
1Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway.
Abstract:
The chapter outlines the management of a great variety of rare intraparenchymal tumors. For some like medulloblastomas or ependymomas, GKNS has little to offer. For others like neurocytomas, primary central nervous system lymphomas, and papillary pineal tumors the current findings look most hopeful. For choroid plexus papillomas there is currently not enough information to define the role of GKNS in their treatment. Pineal region tumors are a complex and varied group of neoplasms. Their complexity, variety and ethnic variability means that defining the role of GKNS will require continuing research before a consensus about management can be reached.
Insights
Gamma Knife non-invasive surgery (GKNS) shows promise for treating rare brain tumors like neurocytomas and lymphomas. Further research is needed to establish its role in managing other rare intraparenchymal tumors.
Area of Science:
- Neurosurgery
- Oncology
- Radiosurgery
Background:
- Intraparenchymal brain tumors encompass a diverse range of rare neoplasms.
- Management strategies for these tumors vary significantly based on tumor type and location.
- The role of specialized treatments like Gamma Knife non-invasive surgery (GKNS) requires ongoing investigation.
Purpose of the Study:
- To review the current management of various rare intraparenchymal tumors.
- To evaluate the potential role and efficacy of Gamma Knife non-invasive surgery (GKNS) in treating these rare neoplasms.
- To identify areas requiring further research for consensus in GKNS application.
Main Methods:
- Literature review of rare intraparenchymal tumors and their management.
- Analysis of existing data on the application of Gamma Knife non-invasive surgery (GKNS).
- Assessment of treatment outcomes and challenges associated with GKNS for specific tumor types.
Main Results:
- GKNS demonstrates limited applicability for tumors such as medulloblastomas and ependymomas.
- Promising outcomes are observed for neurocytomas, primary central nervous system lymphomas, and papillary pineal tumors treated with GKNS.
- Insufficient data currently exists to define the role of GKNS in managing choroid plexus papillomas.
Conclusions:
- GKNS offers potential therapeutic benefits for select rare intraparenchymal brain tumors.
- Continued research is essential to determine the definitive role of GKNS in the management of pineal region tumors due to their complexity and variability.
- Establishing a consensus on GKNS management requires further investigation into its efficacy across diverse rare tumor types.
