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Related Experiment Video

Updated: Oct 5, 2025

Three-Dimensional Reconstruction of Orbital Fractures
08:18

Three-Dimensional Reconstruction of Orbital Fractures

Published on: May 16, 2025

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Orbital indications.

Jeremy C Ganz1

  • 1Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway.

Progress in Brain Research
|January 25, 2022
PubMed
Summary
This summary is machine-generated.

Gamma Knife non-invasive stereotactic radiosurgery (GKNS) offers a valuable eye-sparing treatment for uveal melanoma and other ocular conditions. This advanced technique effectively addresses previously difficult-to-treat tumors, improving patient outcomes.

Keywords:
Choroidal hemangiomaEndocrine ophthalmopathyGlaucomaOptic nerve gliomaOptic nerve sheath meningiomaRhabdomyosarcomaUveal melanoma

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Area of Science:

  • Ophthalmology
  • Neurosurgery
  • Radiation Oncology

Background:

  • Uveal melanoma treatment traditionally risked eye enucleation.
  • Eccentric tumor locations presented significant treatment challenges.
  • Gamma Knife Perfexion technology has advanced ocular tumor management.

Purpose of the Study:

  • To evaluate the efficacy of Gamma Knife non-invasive stereotactic radiosurgery (GKNS) for various ocular conditions.
  • To highlight GKNS as an eye-sparing alternative to enucleation for uveal melanoma.
  • To explore the utility of GKNS beyond uveal melanoma.

Main Methods:

  • Application of Gamma Knife Perfexion for stereotactic radiosurgery.
  • Treatment planning tailored to tumor size, location, and type.
  • Non-invasive delivery of focused radiation to ocular targets.

Main Results:

  • GKNS provides a valued, eye-sparing treatment option for uveal melanoma.
  • Gamma Knife Perfexion overcomes challenges posed by eccentric tumor locations.
  • Unexpected benefits observed in optic nerve gliomas, choroidal hemangiomas, secondary glaucoma, and thyrotoxic ophthalmopathy.

Conclusions:

  • GKNS is a versatile and effective treatment modality for a range of ocular pathologies.
  • The technology enables precise, non-invasive management of challenging eye conditions.
  • GKNS represents a significant advancement in preserving ocular function and avoiding enucleation.