Light emitting CMC-CHO based self-healing hydrogel with injectability for in vivo wound repairing applications

Self-healing hydrogels with biodegradability have great potential biomedical application in drug loading and delivery, wound dressing and tissue engineering. In this research, biodegradable hydrogels were designed from oxidized CMC (CMC-CHO) and PEO₂₃ dinaphthoate hydrazide (PEO₂₃ DNH) with naphthalene structure for potential bio-imaging purpose. Results showed that the gelation time of this self-healing hydrogels was very fit for in situ injectable applications for drug loading and controlled release. The hydrogels also showed excellent biocompatibility because all the components and the acylhydrazone bond are biocompatible. Moreover, the in vitro and in vivo drug release study revealed the CMC-CHO based hydrogels could reduce the acute toxicity of the drugs with a controlled and sustained release manner. The hydrogel also showed hemostatic activity by sealing effect and mEGF loaded hydrogel accelerated the wound repairing efficacy. All above result proved the CMC-CHO/PEO₂₃ DNH hydrogel with luminescent property have great application property in bioscience and biotechnology.