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[Leukocytoclastic vasculitis and acute renal failure following inactivated SARS-CoV-2 vaccine]

Soumia Missoum1, Mourad Lahmar2, Ghalia Khellaf3

  • 1Département de médecine, université de Batna, route de Constantine Fesdis, Batna, Algérie; Service de néphrologie, CHU Benflis Touhami, route de Tazoult, Batna, Algérie.

Nephrologie & Therapeutique
|January 25, 2022
PubMed

SARS-CoV-2 vaccines are being administered worldwide. Most side effects are mild and self-limiting with few reported cases of severe reactions. We report a case of leukocytoclastic vasculitis with acute kidney failure following aninactivated SARS-CoV-2 vaccine, unique for its dramatic visual presentation and its rapid response to treatment. This is the case of a 58years-old man presenting with fever, arthralgias and vascular purpura on his limbs associated with acute kidney failure requiring hemodialysis nine days after anti-COVID-19 vaccination. Skin biopsy revealed a leukocytoclastic vasculitis and a renal biopsy showed an acute tubulointerstitial nephritis. The vascular purpura resolved 7days after initiating treatment with prednisone but the patient remains in chronic renal failure. The analysis and investigation of the complications and adverse events induced by anti-COVID-19 vaccines could increase our understanding of the underlying pathogenesis.

Keywords:
Acute interstitial nephritisCOVID-19 vaccineLeukocytoclastic vasculitisNéphrite interstitielle aiguëVaccin COVID-19Vascularite leucocytoclasique

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