Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

51
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
51
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

1.9K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrasound-Based AI in Predicting Hormone Receptor Status in Breast Cancer: Is "Digital Biopsy" Possible.

Journal of imaging informatics in medicine·2026
Same author

Best Practice Recommendations for the Assessment, Prevention and Treatment of Vitamin D Deficiency in Türkiye: A 2026 Update in a Setting with Limited Mandatory Food Fortification.

Nutrients·2026
Same author

Severe hypocalcemia in a patient with extensive cranial Paget disease: a diagnostic challenge.

JCEM case reports·2026
Same author

Effects of Hybrid-Type Multicomponent Exercise Training on Cardiopulmonary Capacity, Resting Metabolic Rate, and Muscle Strength Following Bariatric Surgery.

Obesity surgery·2026
Same author

Metabolic dysfunction-associated steatotic liver disease in cushing's syndrome: a case controlled FibroScan study.

Journal of endocrinological investigation·2026
Same author

Real-World Comparison of Short-Term Adverse Events, Treatment Persistence, and Efficacy of Semaglutide and Tirzepatide: A Nationwide Multicenter Study.

Obesity facts·2026

Related Experiment Video

Updated: Oct 5, 2025

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

23.7K

Capillary microarchitectural changes in Cushing's syndrome.

Tugce Apaydin1, Yasemin Yalcinkaya2, Can Ilgin3

  • 1Marmara University School of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul, Turkey.

Microvascular Research
|January 25, 2022
PubMed
Summary
This summary is machine-generated.

Cushing's syndrome (CS) patients show microvascular changes in nailfold capillaries, including fewer and wider capillaries, similar to chronic atherosclerotic diseases. These nailfold capillary alterations can help assess cardiovascular risk in CS patients.

Keywords:
Cushing's diseaseCushing's syndrome, capillaroscopy, microcirculationMicroangiopathy

More Related Videos

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.5K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.3K

Related Experiment Videos

Last Updated: Oct 5, 2025

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

23.7K
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.5K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.3K

Area of Science:

  • Endocrinology and Metabolism
  • Cardiovascular Research
  • Microcirculation Studies

Background:

  • Cushing's syndrome (CS) is known for macrovascular complications.
  • Microvascular abnormalities in CS remain less understood.
  • Carotid intima-media thickness (CIMT) is a marker for atherosclerosis.

Purpose of the Study:

  • To investigate microvascular changes in nailfold capillaries of CS patients.
  • To assess the association of these changes with disease status.
  • To correlate microvascular findings with CIMT.

Main Methods:

  • A cross-sectional observational study involving 70 CS patients and 100 controls.
  • Nailfold video-capillaroscopy (NVC) was used to evaluate microvascular structure.
  • Carotid intima-media thickness (CIMT) was measured as an atherosclerosis marker.

Main Results:

  • CS patients had fewer capillaries, wider capillary diameters, and more microhemorrhages compared to controls.
  • Microvascular changes were consistent in both active and remitted CS.
  • Higher CIMT was observed in CS patients, irrespective of disease activity.
  • Capillary number and width correlated with BMI, diabetes, HbA1c, and CIMT.

Conclusions:

  • Nailfold capillary morphology in CS patients shows alterations similar to chronic atherosclerotic conditions.
  • These microvascular changes are present regardless of CS disease status (active vs. remission).
  • NVC assessment of nailfold capillaries can serve as a valuable tool for cardiovascular risk stratification in CS.