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Updated: Oct 5, 2025
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Honokiol suppresses 2,6-dinitrochlorobenzene-induced atopic dermatitis in mice
1Department of Biomedical and Pharmaceutical Sciences, Graduate School and College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea.
Ethnopharmacological Relevance:
Magnolia officinalis constitutes a traditional Korean medicine used for the treatment of atopic dermatitis, and honokiol is an active diphenyl compound present in Magnolia officinalis.
Aim Of The Study:
The aim of the study was to investigate the therapeutic effects of honokiol on atopic dermatitis in vivo.
Materials And Methods:
The therapeutic effects of honokiol were evaluated in a 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis model.
Results:
Administration of honokiol (10 mg/kg) significantly suppressed mast cell accumulation and inflammation induced by DNCB in skin tissues. Moreover, DNCB-induced increases in serum immunoglobulin E levels were reversed by honokiol treatment. In addition, DNCB-induced elevation of inflammatory cytokines (interleukin (IL)-4, IL-13, IL-17, and interferon-γ) in the skin and lymph nodes was significantly ameliorated by honokiol administration. Furthermore, the increase in lymph nodes sizes induced by DNCB treatment was reduced by honokiol administration.
Conclusion:
DNCB-induced atopic responses in the ears and lymph nodes were significantly suppressed by honokiol treatment. These results suggested that honokiol is a potential therapeutic agent for atopic dermatitis.
