Related Experiment Video
Updated: Oct 5, 2025
04:25
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
10.1K
Pulmonary carcinosarcoma with an aggressive heterologous angiosarcoma component: A case report
Jonathan Y Keow1, Richard I Inculet2, Robert Hammond3
1Schulich School of Medicine and Dentistry, Western University; Department of Pathology and Laboratory Medicine, London, Ontario, Canada.
Indian Journal of Pathology & Microbiology
|January 25, 2022
Summary
Pulmonary carcinosarcomas are rare lung cancers. This case highlights an exceptionally rare variant with angiosarcoma, rapidly progressing to metastasis.
Area of Science:
- Oncology
- Pathology
Background:
- Pulmonary carcinosarcomas are rare biphasic lung neoplasms.
- They feature malignant epithelial and mesenchymal components, with common heterologous elements including osteosarcoma, rhabdomyosarcoma, and chondrosarcoma.
Observation:
- This report details an extremely rare pulmonary carcinosarcoma case with heterologous angiosarcoma.
- The tumor also exhibited adenocarcinoma, squamous cell carcinoma, and undifferentiated spindle cell carcinoma.
Findings:
- The patient, a 64-year-old woman, presented with hemoptysis.
- Despite initial resection appearing curative (pT3N0), she rapidly developed widespread metastases, including a hemorrhagic brain metastasis.
- Death occurred 6 weeks post-surgery due to aggressive metastatic disease.
Implications:
- This case underscores the aggressive nature and rarity of pulmonary carcinosarcomas with angiosarcoma components.
- Further understanding of this rare malignancy is crucial for improved patient outcomes.
- Highlights the importance of recognizing diverse histological subtypes in lung cancer diagnosis and management.
