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Updated: Oct 5, 2025

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The Significance of Apolipoprotein-A in the Long-Term Death of Patients with STEMI

Guoli Lin1, Wen Chen1, Caizhi Dai1

  • 1Department of Cardiology, The Affiliated Hospital of Putian University, Putian University, Putian, Fujian, China.

Journal of Healthcare Engineering
|January 25, 2022
PubMed

Insights

Apolipoprotein-A levels can predict long-term mortality risk in patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention. Lower levels indicate a higher risk of death within two years.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Research

Background:

  • Acute ST-segment elevation myocardial infarction (STEMI) is a critical cardiovascular event.
  • Percutaneous coronary intervention (PCI) is a primary treatment for STEMI.
  • Predictive markers for long-term outcomes post-PCI are crucial for patient management.

Purpose of the Study:

  • To evaluate the predictive value of apolipoprotein-A (Apo-A) for long-term mortality in STEMI patients undergoing PCI.
  • To establish a threshold for Apo-A to stratify mortality risk.

Main Methods:

  • A cohort of STEMI patients who underwent emergency PCI was retrospectively analyzed.
  • Patients were stratified into high and low Apo-A groups.
  • Two-year all-cause mortality was assessed using ROC curve, correlation, and Kaplan-Meier analyses.

Main Results:

  • Apo-A levels, along with Apo-B/A ratio, HDL, and hs-CRP, differed significantly between groups.
  • A negative correlation was found between Apo-A and hs-CRP.
  • The low Apo-A group exhibited a higher incidence of 2-year all-cause mortality (AUC=0.626).

Conclusions:

  • Apolipoprotein-A serves as a valuable predictor of long-term mortality in STEMI patients post-PCI.
  • Lower Apo-A levels are associated with increased risk of death.
Abstract

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