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Updated: Oct 5, 2025

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
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Gold micro-particles for knee osteoarthritis.

Sten Rasmussen1,2, Kristian Kjaer Petersen3,4, Martin Kaae Kristiansen3

  • 1Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

European Journal of Pain (London, England)
|January 25, 2022
PubMed
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Intra-articular gold microparticles may reduce knee osteoarthritis pain by modulating immune responses, as indicated by proteomic changes in synovial fluid and serum. Further research is needed to confirm these findings.

Area of Science:

  • Biomedical Engineering
  • Immunology
  • Rheumatology

Background:

  • Knee osteoarthritis (KOA) is a degenerative joint disease characterized by pain and inflammation.
  • Current treatments for KOA often have limited efficacy and potential side effects.
  • Investigating novel therapeutic approaches, such as gold microparticles, is crucial for managing KOA.

Purpose of the Study:

  • To explore the efficacy of intra-articular gold microparticles in reducing pain in patients with KOA.
  • To investigate the immunomodulatory effects of gold microparticles by analyzing proteomic changes in synovial fluid and serum.
  • To assess the impact of gold microparticles on pain, stiffness, and function in KOA patients.

Main Methods:

  • Thirty patients with moderate KOA received intra-articular injections of gold microparticles.

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  • Pain and function were assessed using WOMAC, PainDetect, PPT, TS, and CPM.
  • Proteomic analysis of synovial fluid and serum was performed before and after treatment.

    • Main Results:

    • Significant improvements in pain, stiffness, and function were observed after 8 weeks and 2 years.
    • Proteomic analysis revealed significant changes in protein expression related to immune response and tissue development.
    • No adverse effects were reported, indicating a favorable safety profile.

    Conclusions:

    • Intra-articular gold microparticles show potential for pain relief and immunomodulation in KOA.
    • Proteomic changes in synovial fluid and serum support the anti-inflammatory effects of gold microparticles.
    • Further randomized controlled trials are warranted to validate these findings.