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Updated: Oct 5, 2025

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Synthesis of Furo[2,3-e][1,4]diazepin-3-one Derivatives through Tandem Cyclization/[4 + 3] Annulation Reactions
Bei Zhang1, Jinhang Yu1, Xin Wu1
1Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, People's Republic of China.
Abstract:
A variety of furo[2,3-e][1,4]diazepin-3-one derivatives were facilely synthesized through one-pot tandem cyclization/[4 + 3] annulation reactions between enynamides and α-bromohydroxamates. The reactions proceeded efficiently at room temperature, and various functional groups were well tolerated. The obtained furo[2,3-e][1,4]diazepin-3(2H)-ones containing a 7-membered dinitrogen-fused ring might be of biological and medicinal value. The products could be further derived using convenient procedures.
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