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Delivery of Modified mRNA in a Myocardial Infarction Mouse Model
Published on: June 11, 2020
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Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021
Matthew E Oster1,2,3, David K Shay1, John R Su1
1US Centers for Disease Control and Prevention, Atlanta, Georgia.
JAMA
|January 25, 2022
Summary
COVID-19 vaccination is linked to an increased risk of myocarditis, particularly in adolescent males and young men after the second dose. This risk must be weighed against the significant public health benefits of vaccination.
Area of Science:
- Cardiology
- Immunology
- Public Health
Background:
- COVID-19 vaccination offers public health advantages but carries potential risks, including myocarditis.
- The precise risks and outcomes associated with myocarditis following COVID-19 vaccination remain unclear.
Purpose of the Study:
- To investigate and report cases of myocarditis and their associated reporting rates after mRNA-based COVID-19 vaccination in the United States.
- To describe the clinical characteristics and early outcomes of myocarditis in individuals younger than 30 years old post-vaccination.
Main Methods:
- A descriptive study analyzed myocarditis reports submitted to the Vaccine Adverse Event Reporting System (VAERS) between December 2020 and August 2021.
- Crude reporting rates were calculated and compared to expected rates using claims data. Clinical data were reviewed for cases in individuals under 30.
Main Results:
- Out of over 354 million mRNA COVID-19 vaccine doses administered, 1626 cases met the definition of myocarditis.
- Reporting rates exceeded expected rates across various demographics, with the highest incidence in adolescent males (12-17 years) and young men (18-24 years) after the second vaccine dose.
- In individuals under 30 with available clinical information, 98% had elevated troponin, and 96% were hospitalized, with most experiencing symptom resolution.
Conclusions:
- The risk of myocarditis following mRNA COVID-19 vaccination is elevated in multiple age and sex groups, notably in adolescent males and young men after the second dose.
- This identified risk warrants consideration alongside the established benefits of COVID-19 vaccination.
- Further research may be needed to fully understand the long-term implications and management of post-vaccination myocarditis.
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