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Updated: Oct 5, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

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Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants.

Shuai Li1,2,3, Valentina Silvestri4, Goska Leslie2

  • 1Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|January 25, 2022
PubMed
Summary

Pathogenic variants (PVs) in BRCA1 and BRCA2 genes increase the risk for male breast, pancreatic, and stomach cancers. These findings aid in refining cancer risk management for individuals with BRCA1/2 PVs.

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