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Updated: Oct 5, 2025

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
Published on: October 23, 2015
Adaptive differentiation for fast barrier restoration
Qiutan Yang1, Prisca Liberali1
1Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, 4058 Basel, Switzerland.
Abstract:
Epithelial regeneration can be mediated through activation of stem cells or de-differentiation of post-mitotic cells. In this issue of Developmental Cell, Ohara et al. report that regeneration of damaged intestinal villi occurs via a yes-associated protein 1 (YAP)-dependent adaptive differentiation of transit-amplifying progenitors to a fetal-like state that restores intestinal barrier function.
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