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Investigating genetic overlaps of the genetic factor differentiating schizophrenia from bipolar disorder with
Kazutaka Ohi1, Yukimasa Muto2, Kentaro Takai2
1Department of Psychiatry, Gifu University Graduate School of Medicine, Japan; and Department of General Internal Medicine, Kanazawa Medical University, Japan.
Abstract:
Schizophrenia and bipolar disorder display clinical similarities and dissimilarities. We investigated whether the genetic factor differentiating schizophrenia from bipolar disorder is genetically associated with cognitive phenotypes and hippocampal volumes. We revealed genetic overlaps of the genetic differentiating factor with low general cognitive ability, low childhood IQ, low educational attainment and reduced hippocampal volumes. The genetic correlations with low general cognitive ability and reduced hippocampal volumes were associated with risk of schizophrenia, whereas the genetic correlations with high childhood IQ and educational attainment were associated with risks of bipolar disorder. These findings suggest these disorders have disorder-specific genetic factors related to clinical phenotypes.
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