[Advances in the mechanism of bacterial escape neutrophil killing]

The innate immune system is the forefront defense against bacterial invasion in human body. Neutrophils, as major immune cells, can capture and phagocytose bacteria, which are indispensable for maintaining the health of the body. Pathogens such as Streptococcus, Neisseria meningitidis, Klebsiella, Escherichia coli, Pseudomonas aeruginosa, Haemophilus influenzae, Staphylococcus aureus, and Mycobacterium tuberculosis have evolved multiple mechanisms to circumvent killing by neutrophils outside and inside the cells, even taking cells as their survival and breeding sites. These mechanisms include interfering with neutral granulocyte collection and phagocytosis, degrading neutrophil extracellular traps, inhibiting the production of reactive oxygen and antimicrobial peptides, and manipulating the life-span and death of cells.