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Asthma in paediatric intensive care in England residents: observational study

Mome Mukherjee1,2, Steve Cunningham3,4, Mohammad Romel Bhuia3

  • 1Asthma UK Centre for Applied Research, Usher Institute, The University of Edinburgh, Edinburgh, UK. mome.mukherjee@ed.ac.uk.

Scientific Reports
|January 26, 2022
PubMed

Insights

Children admitted to paediatric intensive care units (PICUs) for asthma were more likely to be from deprived areas. This highlights a need for enhanced community asthma support for socioeconomically disadvantaged children.

Area of Science:

  • Pediatric Intensive Care
  • Respiratory Medicine
  • Public Health

Background:

  • Asthma is prevalent in UK children.
  • No previous studies reported on pediatric intensive care unit (PICU) admissions for childhood asthma in England.
  • This study addresses this gap by investigating asthma admissions in PICUs.

Purpose of the Study:

  • To investigate the epidemiology of childhood asthma admissions to PICUs in England.
  • To examine healthcare resource utilization for pediatric asthma patients in PICUs.
  • To identify demographic and socioeconomic factors associated with severe asthma exacerbations requiring PICU admission.

Main Methods:

  • Utilized data from PICANet, a UK national PICU database.
  • Included children resident in England admitted to PICU for asthma as the primary diagnosis.
  • Analyzed data from April 2006 to March 2013.

Main Results:

  • 2195 PICU admissions for asthma were recorded.
  • Males (59%) and younger children (0-4 years, 51%) predominated.
  • Children from the most deprived quintiles accounted for 61% of admissions and 73% of deaths.
  • Invasive ventilation was required for 38% of admissions, increasing with deprivation and decreasing with age.
  • Deaths were most frequent in 10-14 year olds.

Conclusions:

  • Children from socioeconomically deprived neighborhoods represent a disproportionate number of severe asthma admissions, ventilation, and deaths in English PICUs.
  • Socioeconomic deprivation is a significant factor in severe pediatric asthma.
  • Enhanced community-based asthma support may benefit children experiencing socioeconomic disadvantage.

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