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Published on: January 28, 2020
Mean platelet volume as a simple marker of repeated coronary artery intervention after off-pump technique (OPCAB)
Tomasz K Urbanowicz1, Michał Michalak2, Weronika Mikołajewska3
1Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, Poznan, Poland.
Insights
Mean platelet volume (MPV) may predict percutaneous coronary intervention (PCI) risk after off-pump coronary artery bypass grafting (OPCAB). Higher MPV levels indicate a greater risk for adverse cardiac events post-surgery.
Area of Science:
- Cardiology
- Vascular Surgery
- Biomarker Research
Background:
- Mean platelet volume (MPV) is a potential predictor of major adverse cardiac events (MACE) after percutaneous coronary interventions (PCI).
- The utility of MPV in predicting PCI risk in patients with complex coronary artery disease undergoing off-pump coronary artery bypass grafting (OPCAB) requires further investigation.
Purpose of the Study:
- To investigate the association between MPV and postoperative PCI risk in patients with complex coronary artery disease undergoing OPCAB.
- To determine if MPV can serve as a predictive marker for long-term adverse cardiac events following OPCAB procedures.
Main Methods:
- Retrospective analysis of 236 patients with complex coronary artery disease undergoing OPCAB between 2015 and 2016.
- A mean follow-up of 5.1 years was conducted, analyzing MACE, including acute coronary syndromes and PCI.
- Logistic regression models (univariate and multivariate) were used to assess the predictive value of preoperative and postoperative parameters, including MPV.
Main Results:
- A total of 213 patients completed the 5-year follow-up, with a 1-year mortality rate of 2%.
- Preoperative white blood cell count and postoperative MPV were identified as significant predictors of long-term PCI risk.
- Postoperative MPV (cutoff > 8.7 fL) showed an odds ratio of 1.76 (95% CI, p=0.005) in multivariate analysis for predicting PCI risk.
Conclusions:
- Mean platelet volume (MPV) is a simple and effective marker for predicting PCI risk after OPCAB procedures.
- Preoperative MPV levels appear to reflect an individual's predisposition to poorer long-term prognosis more than the procedure itself.
Introduction:
Mean platelet volume (MPV) is claimed to be a useful marker to predict long-term risk for major adverse cardiac effects (MACE) in patients undergoing percutaneous coronary interventions (PCI).
Aim:
To explore the possible dependence on MPV and postoperative PCI risk in patients with complex coronary artery disease undergoing coronary artery bypass grafting in off-pump technique (OPCAB).
Material And Methods:
We retrospectively analyzed 236 consecutive patients (180 (76%) males and 56 (24%) women) referred for surgery due to complex coronary artery disease between 2015 and 2016 in our department. The mean 5.1 ±0.8 year follow-up included profound analysis of MACE events including acute coronary syndromes and percutaneous interventions.
Results:
The 5 ±1 year follow-up was completed by 213 (90%) patients with 2 (1%) deaths within the first year after surgery. In logistic univariate and multivariate model regression analysis two parameters were found significant, i.e. preoperative white blood cells and postoperative MVP, for PCI risk in long-term follow-up. The odds ratio values for postoperative MPV were 1.78 (95% CI, p = 0.0036) and 1.76 (95% CI, p = 0.005) in univariate and multivariate models with cutoff point > 8.7, sensitivity 45.65%, specificity 78.72%.
Conclusions:
MPV can be regarded as a simple marker of PCI risk following OPCAB procedures. The preoperative MPV indicates the individual tendency for worse prognosis more than procedure dependence.
