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Bilateral open lip schizencephaly.

Turyalai Hakimi¹, Khalid Mohammad Qasem²

¹Department of Pediatric Surgery, Kabul University of Medical Science, Maiwand Teaching Hospital, Kabul, Afghanistan.

Annals of Medicine and Surgery (2012)

|January 26, 2022

Summary

This summary is machine-generated.

Schizencephaly, a CNS disorder, involves abnormal cerebral clefts. A case of bilateral open lip schizencephaly with neurological issues improved after a ventriculo-peritoneal shunt procedure.

Keywords:

Cleft Closed lip Developmental disorder Open lip Schizencephaly Ventriculomegaly

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Area of Science:

Neurology
Developmental Biology
Pediatrics

Background:

Schizencephaly is a rare central nervous system (CNS) developmental disorder.
It is characterized by abnormal clefts extending from the lateral ventricles to the cerebral cortex.
Etiologies include genetic factors, teratogen exposure, viral infections, and advanced maternal age.

Observation:

A case of bilateral open lip schizencephaly presented with neurological deficits.
The patient exhibited increased intracranial pressure (ICP) secondary to ventriculomegaly.
Clinical presentation included significant neurological impairments.

Findings:

The patient underwent a ventriculo-peritoneal (V-P) shunt procedure.
Post-operative follow-up revealed considerable clinical improvement.
The V-P shunt effectively managed the increased ICP and associated neurological symptoms.

Implications:

This case highlights the efficacy of V-P shunting in managing complex schizencephaly.
Early intervention with CSF diversion may improve neurological outcomes in affected individuals.
Further research into the genetic and environmental factors of schizencephaly is warranted.