Anticoagulated de novo atrial flutter complicated by transitory ischemic attack in fatal COVID-19

SARS-CoV-2 may not only manifest as pneumonia (COVID-19) but also in other organs, including the brain (neuro-COVID). One of the cerebral complications of SARS-CoV-2 is ischemic stroke. Transitory ischemic attack (TIA) in a SARS-CoV-2 positive has not been reported. A 78-year-old poly-morbid male (diabetes, hypertension, and coronary heart disease), admitted for COVID-19, developed atrial flutter on hospital day (hd) 2. Anticoagulation with enoxaparin was started. On hd5, he experienced a TIA despite sufficient anticoagulation. The patient expired on hd28 due to multi-organ failure from sepsis due to superinfection with staphylococcus aureus. Infection with SARS-CoV-2 may be complicated by atrial flutter. Atrial flutter may be complicated by TIA despite sufficient anticoagulation, suggesting that standard anticoagulation may be insufficient to meet SARS-CoV-2-associated hypercoagulability syndrome. Forced anticoagulation and adequate antibiosis in poly-morbid SARS-CoV-2-infected patients with hypercoagulability and cytokine storm are warranted.