Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiac Risk After Heart-Sparing Breast Radiotherapy.

JAMA oncology·2026
Same author

Heart Substructure Radiation Dose and Cardiac Outcomes: Contemporary Evidence and Actionable Opportunities: JACC CardioOncology State-of-the-Art Review.

JACC. CardioOncology·2026
Same author

GLP-1 Receptor Agonists and Cardiovascular Events During Androgen Receptor Pathway Inhibitor Therapy.

medRxiv : the preprint server for health sciences·2026
Same author

The CHRONO trial: Protocol for a randomized controlled trial of early time-restricted eating in patients with breast or rectal cancer.

Nutrition research (New York, N.Y.)·2026
Same author

Patient engagement with consumer wearable devices in the electronic health record.

Frontiers in digital health·2026
Same author

The role of ovarian transposition prior to pelvic radiation: A review.

Gynecologic oncology reports·2026

Related Experiment Video

Updated: Oct 5, 2025

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.3K

Ovarian Transposition Before Pelvic Radiation Therapy: Spatial Distribution and Dose Volume Analysis.

Christopher Gay1, Yaniv R Raphael2, Jennifer Steers1

  • 1Department of Radiation Oncology.

Advances in Radiation Oncology
|January 26, 2022
PubMed
Summary

Surgically transposed ovaries often receive high radiation doses, risking ovarian failure despite placement outside the planning target volume (PTV). More effective ovary-sparing strategies are needed for patients undergoing pelvic radiation therapy (RT).

More Related Videos

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
10:58

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

11.0K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.5K

Related Experiment Videos

Last Updated: Oct 5, 2025

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.3K
Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
10:58

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

11.0K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.5K

Area of Science:

  • Reproductive medicine
  • Radiation oncology
  • Gynecologic oncology

Background:

  • Pelvic radiation therapy (RT) poses a risk to ovarian function.
  • Ovarian transposition is a technique to preserve fertility and hormonal function.
  • Data on the precise location and radiation dose to transposed ovaries is limited.

Purpose of the Study:

  • To analyze the anatomic locations and radiation dose metrics of surgically transposed ovaries in patients receiving pelvic RT.
  • To evaluate the effectiveness of ovarian transposition in shielding ovaries from RT.
  • To inform surgical and RT planning for improved ovarian preservation.

Main Methods:

  • Retrospective analysis of women undergoing ovarian transposition before pelvic RT (2010-2020).
  • Measurement of ovarian position relative to sacral promontory, iliac crest, and RT planning target volume (PTV).
  • Calculation of radiation dose (mean and maximum) to transposed ovaries.

Main Results:

  • Thirty-one ovaries from 18 patients were analyzed.
  • Most ovaries (64.5%) were located outside the PTV and above the sacral promontory.
  • Despite being outside the PTV, median ovarian doses were 15.5 Gy (mean) and 32.2 Gy (maximum), associated with high failure risk.
  • Distance from the iliac crest was a significant predictor of ovary location outside the PTV.

Conclusions:

  • Transposed ovaries often receive high radiation doses, increasing the risk of ovarian failure.
  • Current transposition techniques may not sufficiently shield ovaries from pelvic RT.
  • More aggressive ovary-sparing strategies are necessary to improve fertility and hormonal preservation outcomes.