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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Author response to Letter to the Editor by Yang et al. regarding Radiofrequency echographic multispectrometry in total hip arthroplasty: validation and clinical translation.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
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An invited rebuttal letter. Author response to: OSIN-D-25-02044: Critical considerations on the article by Bobelyak et al. (2025) "Bone mineral density assessment using radiofrequency echographic multispectrometry (REMS) in patients before and after total hip replacement"; https://doi.org/10.1007/s00198-025-07685-w.

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Author response to: OSIN-D-25-01882: Concerns regarding "Bone mineral density assessment using radiofrequency echographic multispectrometry (REMS) in patients before and after total hip replacement".

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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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A decrease in serum 1,25(OH)2D after elective hip replacement and during bone healing is associated with changes in

J Vaculik1,2,3, L Wenchich4, M Bobelyak1,2

  • 1Orthopedic Department, Bulovka Hospital, Prague, Czech Republic.

Journal of Endocrinological Investigation
|January 26, 2022
PubMed
Summary
This summary is machine-generated.

Calcitriol (active vitamin D) production decreases after hip replacement surgery. Changes in calcitriol conversion correlate with fibroblast growth factor 23 (FGF23) and iron status, suggesting a link to bone healing complications.

Keywords:
CalcitriolElective hip replacementFibroblast growth factor 23IronTotal 25 hydroxyvitamin D

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Area of Science:

  • Orthopedic Surgery
  • Endocrinology
  • Nutritional Biochemistry

Background:

  • Calcitriol is vital for bone healing, but its levels drop post-hip surgery.
  • Understanding factors affecting calcitriol levels is crucial for optimizing recovery.

Purpose of the Study:

  • To investigate the association between calcitriol production changes and fibroblast growth factor 23 (FGF23) and iron status after hip replacement.
  • To explore the relationship between vitamin D metabolism and key hormonal and nutritional markers.

Main Methods:

  • Prospective study of 17 patients undergoing elective hip replacement.
  • Biomarker analysis including 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, FGF23 (intact and C-terminal), and iron status markers (transferrin, ferritin) at multiple time points.
  • Calculation of the conversion rate of 25(OH)D to 1,25(OH)2D and the ratio of intact to C-terminal FGF23.

Main Results:

  • Significant correlations were observed between the percent change in 25(OH)D to 1,25(OH)2D conversion rate, the intact to C-terminal FGF23 plasma ratio, and serum iron levels.
  • These correlations were evident both early post-surgery and at 7 weeks.

Conclusions:

  • Calcitriol production is impaired following hip replacement surgery, resulting in lower active vitamin D serum levels.
  • The identified correlations suggest a complex interplay between vitamin D metabolism, FGF23, and iron status post-surgery.
  • Further research is warranted to determine the clinical implications and potential interventions for calcitriol deficiency in fracture and post-operative settings.