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Intercalation-Activated Layered MoO3 Nanobelts as Biodegradable Nanozymes for Tumor-Specific Photo-Enhanced Catalytic
Zhan Zhou1,2, Yanlong Wang3,4, Feng Peng5
1College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang, 471934, P. R. China.
Angewandte Chemie (International Ed. in English)
|January 26, 2022
Summary
Layered molybdenum trioxide (MoO3) nanobelts were activated into nanozymes using aqueous intercalation. These nanozymes generate reactive oxygen species for enhanced, tumor-specific photothermal therapy.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Layered materials offer tunable properties via intercalation.
- Molybdenum trioxide (MoO3) nanostructures are explored for catalytic applications.
Purpose of the Study:
- To activate MoO3 nanobelts into biodegradable nanozymes for cancer therapy.
- To enhance catalytic activity through intercalation and photothermal effects.
Main Methods:
- Aqueous intercalation of MoO3 nanobelts with Na+ and H2O to form Na+/H2O co-intercalated MoO3-x (NH-MoO3-x) nanobelts.
- Evaluation of enzyme-mimicking catalytic activity and reactive oxygen species generation.
- In vitro and in vivo studies of tumor-specific photo-enhanced catalytic therapy using a 1064 nm laser.
Main Results:
- Intercalated NH-MoO3-x nanobelts exhibit significant enzyme-mimicking activity, unlike pristine MoO3.
- Catalytic activity is enhanced by the photothermal effect under 1064 nm laser irradiation.
- BSA-modified NH-MoO3-x effectively kills cancer cells and eliminates tumors in vivo.
Conclusions:
- Aqueous intercalation is an effective method to activate MoO3 nanobelts into biodegradable nanozymes.
- NH-MoO3-x nanozymes show promise for tumor-specific photo-enhanced catalytic therapy.
- This approach offers a novel strategy for advanced cancer treatment.
