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The history of the drug-induced enterocolitis syndrome

Elio Novembre1, Simona Barni1, Francesca Saretta2

  • 1Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|January 26, 2022
PubMed

Insights

Drug-induced enterocolitis syndrome (DIES) mimics food protein-induced enterocolitis syndrome (FPIES) but is triggered by medications. Further research is needed to understand DIES pathogenesis, natural history, and genetic factors.

Area of Science:

  • Allergy and Immunology
  • Pediatric Gastroenterology
  • Clinical Pharmacology

Background:

  • Drug-induced enterocolitis syndrome (DIES) is a recently identified condition.
  • DIES shares clinical similarities with food protein-induced enterocolitis syndrome (FPIES).
  • Currently, only ten cases of DIES have been documented.

Purpose of the Study:

  • To highlight the clinical characteristics of DIES.
  • To emphasize the need for increased awareness and research into DIES.
  • To differentiate DIES from FPIES and other gastrointestinal disorders.

Main Methods:

  • Literature review of published DIES cases.
  • Clinical comparison between DIES and FPIES.
  • Analysis of diagnostic challenges and management strategies.

Main Results:

  • DIES is clinically similar to FPIES but is drug-induced.
  • Pathogenesis, natural history, and genetic factors of DIES remain largely unknown.
  • Accurate recognition and management of DIES are crucial but challenging.

Conclusions:

  • DIES is an emerging clinical entity requiring further investigation.
  • Allergists and pediatric specialists should be aware of DIES.
  • Understanding DIES pathogenesis is essential for improved patient care.
Keywords:
drug-induced enterocolitis syndromefood protein-induced enterocolitis syndromehistorypediatricsrare allergic diseases

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