Macroporous Adhesive Nano-Enabled Hydrogels Generated from Air-in-Water Emulsions
Manshan Xie1, Zhiwen Zheng2,3,4, Shiheng Pu2
1School of Biomedical Science and Engineering, South China University of Technology, Guangzhou, 511442, China.
Macromolecular Bioscience
|January 26, 2022
Summary
This study reports a new macroporous hydrogel for wound healing. The advanced nanocomposite hydrogel offers adjustable mechanical properties, tissue adhesion, and enhanced blood coagulation for surgical applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Developing advanced wound healing materials is crucial for surgical applications.
- Current materials often lack multi-functionality, including tunable mechanical properties and effective hemostasis.
Purpose of the Study:
- To create a macroporous, adhesive nanocomposite hydrogel with adjustable mechanical properties, tissue adhesion, and blood coagulation capabilities.
- To accelerate wound healing and improve surgical outcomes.
Main Methods:
- Fabrication of a macroporous hydrogel using gelatin methacryloyl stabilized emulsions.
- Incorporation of dopamine-grafted-gelatin (GelDA) and Laponite nanoclay.
- Characterization of mechanical properties, self-healing, tissue adhesion, and blood coagulation in vitro.
Main Results:
- The hydrogel exhibits an interconnected macroporous structure and tunable mechanical strength via Laponite nanoclay concentration.
- The material demonstrates self-healing properties and effective tissue adhesion.
- In vitro studies confirmed good biocompatibility and significantly reduced blood clotting time.
Conclusions:
- The developed nanocomposite hydrogel possesses multi-functional properties suitable for surgical wound management.
- This macroporous hydrogel shows potential for rapid sealing and hemostasis of bleeding wounds.
- Further applications in accelerating wound healing are anticipated.
