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Related Experiment Video

Updated: Oct 5, 2025

Layer-by-layer Synthesis and Transfer of Freestanding Conjugated Microporous Polymer Nanomembranes

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Published on: December 15, 2015

Glycopolymer Based LbL Multilayer Thin Films with Embedded Liposomes.

Jo Sing Julia Tang^1,2, Aline Debrassi Smaczniak³, Lucas Tepper¹

¹Fraunhofer Institute for Applied Polymer Research IAP, Biofunctionalized Materials and (Glyco)Biotechnology, Geiselbergstr. 69, Potsdam, 14476, Germany.

Macromolecular Bioscience

|January 26, 2022

Summary

This study presents a new method for creating glycopolymer coatings using layer-by-layer (LbL) self-assembly. These coatings effectively support intact liposomes for potential drug delivery applications.

Keywords:

glycopolymers layer-by-layer self-assembly liposomes polyelectrolyte multilayer film

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Last Updated: Oct 5, 2025

Layer-by-layer Synthesis and Transfer of Freestanding Conjugated Microporous Polymer Nanomembranes

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Published on: December 15, 2015

Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film

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Published on: July 10, 2016

Fabrication of Large-area Free-standing Ultrathin Polymer Films

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Published on: June 3, 2015

Area of Science:

Materials Science
Polymer Chemistry
Biotechnology

Background:

Layer-by-layer (LbL) self-assembly is a versatile technique for fabricating functional coatings.
Bioinspired glycopolymer electrolytes offer potential for advanced material applications.
Liposomes are widely investigated for drug delivery due to their encapsulation capabilities.

Purpose of the Study:

To develop a protecting group-free, aqueous synthesis of bioinspired glycopolymer electrolytes.
To fabricate glycopolymer thin films using LbL self-assembly as scaffolds for liposomes.
To characterize the stability and integrity of these glycopolymer coatings and embedded liposomes.

Main Methods:

Synthesized bioinspired glycopolymer electrolytes using a protecting group-free, aqueous-based approach.
Fabricated glycopolymer thin films via LbL self-assembly.
Investigated coating properties and liposome integrity using whispering gallery mode (WGM) technology and quartz crystal microbalance with dissipation (QCM-D) monitoring.

Main Results:

Successfully synthesized bioinspired glycopolymer electrolytes in an aqueous environment.
Demonstrated LbL self-assembly of glycopolymer thin films capable of scaffolding liposomes.
Confirmed the stability of glycopolymer coatings and the integrity of embedded liposomes across a physiological pH range using WGM and QCM-D.

Conclusions:

Developed a novel, environmentally friendly method for glycopolymer synthesis and LbL film fabrication.
Presented glycopolymer-based surface coatings as effective scaffolds for intact liposomes.
Highlighted the potential of these glycopolymer-liposome systems for applications such as drug delivery.