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Related Experiment Video

Updated: Oct 5, 2025

Automated Measurement of Cryptococcal Species Polysaccharide Capsule and Cell Body

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Published on: January 11, 2018

Capsule Machine Validation.

Antoine Al-Achi¹, Tysheon McGreggor², Shreelekha Jaligama³

¹Campbell University College of Pharmacy & Health Sciences, Buies Creek, North Carolina. alachi@campbell.edu.

International Journal of Pharmaceutical Compounding

|January 26, 2022

Summary

This summary is machine-generated.

This study validates a capsule machine for compounding acetaminophen, demonstrating high accuracy and reproducibility for pharmaceutical preparations. The affordable instrument is suitable for pharmacy compounding and student training.

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Area of Science:

Pharmaceutical Compounding
Pharmaceutics
Drug Delivery Systems

Background:

Instrumentation is crucial for efficient hard-gelatin capsule compounding.
The Capsule Machine from Capsule Connection LLC offers a cost-effective solution for preparing capsules.
This machine is suitable for both herbal/vitamin preparations and pharmacy student training.

Purpose of the Study:

To calibrate and validate a capsule formulation for acetaminophen using the Capsule Machine.
To assess the accuracy, reproducibility, and efficiency of the capsule machine in a simulated compounding operation.

Main Methods:

Twenty Capsule Machines were calibrated and validated using spray-dried lactose monohydrate.
Acetaminophen powder was mixed with lactose using geometric dilution for capsule formulation.
United States Pharmacopeia (USP) content uniformity tests were performed on the compounded capsules.

Main Results:

All tested capsule machines successfully passed the USP content uniformity test.
The average acetaminophen content per capsule was 98.91% of the labeled amount, indicating high accuracy.
Minimal powder loss (<5% for lactose, 0% for acetaminophen) was observed, highlighting operational efficiency.

Conclusions:

The Capsule Machine from Capsule Connection LLC demonstrates high reproducibility and accuracy for compounding acetaminophen capsules.
This instrument is a viable tool for pharmaceutical compounding operations and educational purposes in pharmaceutics.
The study confirms the machine's reliability for producing accurately dosed capsules meeting USP standards.