Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kali MC: an open-source toolkit for intraoperative electron radiation therapy treatment planning.

Biomedical physics & engineering express·2026
Same author

Development and characterisation of a radiobiology proton beamline using radiochromic film dosimetry.

Physics in medicine and biology·2026
Same author

Extending the microdosimetry gamma model (MGM) to estimate induced DNA damage and its complexity at macroscopic scale by protons and helium ions.

Physics in medicine and biology·2025
Same author

Atherosclerotic disease activity is associated with glycolytic enzyme expression across multiple cell types and is trackable by FDG-PET.

Science translational medicine·2025
Same author

Analytical positron range model for PET with cross-code Monte Carlo benchmarking.

Physics in medicine and biology·2025
Same author

Characterization of silicon carbide diodes as cost-effective active detectors for proton UHDR dosimetry.

Medical physics·2025

Related Experiment Video

Updated: Oct 5, 2025

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

15.9K

Dictionary-based software for proton dose reconstruction and submilimetric range verification.

V V Onecha1,2, P Galve1,2, P Ibáñez1,2

  • 1Grupo de Física Nuclear, EMFTEL & IPARCOS, Universidad Complutense de Madrid, CEI Moncloa, Madrid, Spain.

Physics in Medicine and Biology
|January 26, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a new method for precise proton range verification in proton therapy. It enables accurate dose reconstruction from PET data, even at low doses, improving treatment safety.

Keywords:
MLEM algorithmPET imagingproton dose reconstructionproton range verificationproton therapy

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.5K
Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

15.5K

Related Experiment Videos

Last Updated: Oct 5, 2025

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

15.9K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.5K
Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

15.5K

Area of Science:

  • Medical Physics
  • Radiotherapy
  • Nuclear Medicine

Background:

  • Proton therapy offers precise dose delivery but requires accurate range verification.
  • Current methods for dose reconstruction and range verification can be limited in precision and speed.
  • Positron Emission Tomography (PET) offers a potential imaging modality for in-vivo dosimetry during proton therapy.

Purpose of the Study:

  • To develop and validate a novel, fast, and in-beam compatible method for reconstructing deposited dose distributions during proton therapy.
  • To achieve noiseless dose reconstructions for highly precise proton range determination.
  • To enable accurate dose verification at clinically relevant low dose levels (down to 1 Gy).

Main Methods:

  • A new MLEM & simulated annealing (MSA) algorithm was developed for dose reconstruction.
  • The algorithm utilizes a pre-calculated activity-dose dictionary derived from Monte Carlo simulations.
  • It reconstructs dose by finding a linear combination of precomputed beam activities that best fits observed PET data, incorporating prior treatment plan information.

Main Results:

  • The MSA method successfully reconstructed dose distributions from simulated PET data.
  • Accurate dose reconstruction was achieved for irradiations as low as 1 Gy.
  • The method demonstrated the ability to detect proton range variations as small as 0.6 mm, with overall range accuracy better than 1 mm.

Conclusions:

  • The developed method provides accurate dose reconstruction from PET data at clinically relevant dose levels.
  • The noiseless nature of the reconstructed dose maps enables highly precise proton range verification.
  • This technique presents a viable option for real-time, in-beam range verification in proton therapy, enhancing treatment safety and accuracy.