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Updated: Jul 31, 2026

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Intravitreous Injection for Establishing Ocular Diseases Model
Published on: October 1, 2007
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INTRAOCULAR LYMPHOMA WITH RETROBULBAR INFILTRATION. A CASE REPORT
Summary
Intraocular lymphoma can mimic other eye conditions, delaying diagnosis and treatment. Early suspicion and histological verification are crucial for managing this rare malignancy.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Intraocular lymphoma, often presenting as uveitis, can be misdiagnosed due to non-specific symptoms.
- A high index of suspicion and a multidisciplinary diagnostic approach are essential for timely intervention.
Observation:
- A 78-year-old patient experienced progressive vision loss, initially suspected as retinal detachment.
- Ophthalmological examination revealed decreased visual acuity and fluctuating intraocular pressure.
- Imaging studies confirmed an intraocular tumor with retrobulbar infiltration and retinal detachment.
Findings:
- Enucleation facilitated the diagnosis of intraocular B-Non-Hodgkin lymphoma, specifically marginal zone B-cell type.
- The patient received a prosthesis and was referred for further hematologist-oncologist management.
- No adjuvant therapy was administered for 15 months post-enucleation, with the patient under observation.
Implications:
- Enucleation served as both a diagnostic and therapeutic measure in this case.
- This case highlights the importance of considering intraocular lymphoma in the differential diagnosis of inflammatory or tumor-like eye conditions.
- Further research into optimal management strategies for intraocular lymphoma is warranted.

