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Related Experiment Videos

Microencapsulation of soluble pharmaceuticals.

S K Baveja1, K V Rao, Y Kumar

  • 1Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.

Journal of Microencapsulation
|January 1, 1986
PubMed
Summary

A novel method effectively microencapsulates water-soluble drugs like diethylcarbamazine citrate into spherical particles. This technique offers high yield and precise particle size control for drug delivery applications.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Microencapsulation is crucial for controlled drug delivery.
  • Developing efficient methods for water-soluble drugs remains a challenge.

Purpose of the Study:

  • To develop a novel microencapsulation technique for water-soluble drugs.
  • To optimize particle characteristics like size, shape, and yield.

Main Methods:

  • A gelatin-drug dispersion was sprayed into chilled liquid paraffin.
  • Spherical microcapsules were formed via gelation, freeze-drying, and solvent washing.
  • Diethylcarbamazine citrate served as the model drug.

Main Results:

  • Spherical, discrete microcapsules of approximately 175 microns were produced with excellent yield.
  • The method demonstrated control over particle size, shape, and distribution.
  • Optimization of various factors influenced microencapsulation efficiency.

Conclusions:

  • The described method is effective for microencapsulating water-soluble drugs.
  • This technique offers a promising approach for pharmaceutical formulation.
  • The process allows for tunable particle characteristics for drug delivery.

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