Sorption of 5-fluorouracil from aqueous solutions onto methyl methacrylate nanoparticles

The sorption of 5-fluorouracil from aqueous solutions onto poly(methyl methacrylate) was investigated. Linear sorption isotherms were obtained and no crystallinity of the nanoparticles after sorption was detectable by X-ray analysis indicating a partitioning of the drug into the polymer particles-forming a solid solution. Standard enthalpy, standard entropy and standard free energy of sorption were -36.9 kJ mol-1, -85.0 J mol-1 K-1 and -12.0 kJ mol-1, respectively.