Related Experiment Video
Updated: Oct 5, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.4K
Brain barriers and their potential role in migraine pathophysiology
Astrid Wiggers1, Håkan Ashina1,2, Nouchine Hadjikhani3
1Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Valdemar Hansens Vej 5, DK-2600, Glostrup, Denmark.
The Journal of Headache and Pain
|January 27, 2022
Summary
Migraine attacks may be triggered by vasoactive peptides crossing the brain barrier. This review explores evidence for brain barrier dysfunction in migraine, suggesting a potential therapeutic target.
Area of Science:
- Neurology
- Neuroscience
- Molecular Pathogenesis
Background:
- Migraine is a common neurological disorder affecting all ages.
- Vasoactive peptides released from cranial nerves are implicated in migraine.
- The exact site of action for these peptides is debated.
Purpose of the Study:
- To review evidence linking brain barrier dysfunction to migraine.
- To explore the role of brain barrier permeability in migraine pathogenesis.
- To identify future research directions.
Main Methods:
- Literature review of studies on brain barriers and migraine.
- Analysis of experimental data on vasoactive peptides and migraine induction.
- Synthesis of evidence for transient brain barrier dysfunction.
Main Results:
- Vasoactive peptides can induce migraine attacks.
- Evidence suggests potential transient dysfunction of brain barriers in migraine.
- This dysfunction may allow peptides to enter the central nervous system.
Conclusions:
- Brain barrier dysfunction is a plausible factor in migraine pathogenesis.
- Targeting brain barrier integrity could be a future therapeutic strategy.
- Further research is needed to elucidate the precise mechanisms.
Related Concept Videos
00:49The Blood-brain Barrier
49.5K
Overview
49.5K
01:19Ion Channels
88.7K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
88.7K
01:25Physiological Barriers
4.3K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
4.3K
01:23Factors Affecting Drug Distribution: Physiological Barriers
397
Drug distribution in the body is intricately regulated by various physiological barriers that control the passage of substances. These include the capillary endothelial barrier, the blood-brain, blood-cerebrospinal fluid, blood-placental, and blood-testis barriers.
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
397
01:22Pathophysiology of Vomiting
1.3K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
1.3K
01:19Cranial and Spinal Meninges
1.9K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
1.9K